Health & Medicine - Posted by Tim Green-U. Texas on Tuesday, September 28, 2010 9:50 - 1 Comment 
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(3 votes, average: 5.00 out of 5) Loading ...Stress negates effects of testosterone
When cortisol increases during an emergency situation, the body is mobilized to escape danger, rather than respond to any influence that testosterone may have on behavior. (Credit: iStockphoto)
U. TEXAS-AUSTIN (US) — High levels of the stress hormone cortisol play a critical role in blocking testosterone’s influence on competition and domination.
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Findings of a new study, available online in Hormones and Behavior, show that when cortisol—a hormone released in the body in response to threat—increases, the body is mobilized to escape danger, rather than respond to any influence that testosterone is having on behavior.
The study provides new evidence that hormonal axes (complex feedback networks between hormones and particular brain areas that regulate testosterone levels and cortisol) work against each other to regulate dominant and competitive behaviors.
“It makes good adaptive sense that testosterone’s behavioral influence during an emergency situation gets blocked because engaging in behaviors that are encouraged by testosterone, such as mating, competition, and aggression, during an imminent survival situation could be fatal,” says Robert Josephs, professor of psychology at the University of Texas at Austin, who led the study with Pranjal Mehta, assistant professor of psychology at the University of Oregon.
“On the other hand, fight or flight behaviors encouraged by cortisol become more likely during an emergency situation when cortisol levels are high. Thus, it makes sense that the hormonal axes that regulate testosterone levels and cortisol levels are antagonistic.”
As part of the study, researchers measured hormone levels of saliva samples provided by 57 subjects. The respondents participated in a one-on-one competition and were given the opportunity to compete again after winning or losing.
Among those who lost, 100 percent of the subjects with high testosterone and low cortisol requested a rematch to recapture their lost status. However, 100 percent of participants with high testosterone and high cortisol declined to compete again.
All subjects who declined a rematch experienced a significant drop in testosterone after defeat, which may help to explain their unwillingness to compete again, Josephs says.
The researchers suggest these findings reveal new insights into the physiological effects of stress and how they may play a role in fertility problems.
Chronically elevated cortisol levels can produce impotence and loss of libido by inhibiting testosterone production in men. In women, chronically high levels of cortisol can produce severe fertility problems and result in an abnormal menstrual cycle.
“When cortisol levels remain elevated, as is the case with so many people who are under constant stress, the ability to reproduce can suffer greatly,” Josephs says.
“However, these effects of cortisol in both men and women are reversed when stress levels go down.”
More news from University of Texas at Austin: www.utexas.edu/news/
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1 Comment
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Totally agree, Stress and cortisol is a big killer ! If the stressor is not eliminated soon after the episodic event (for example, a soldier may not be able to leave the battlefield, or a child may not be able to flee abuse at home), then high cortisol levels continue to exist in the body, keeping other systems compromised like those driven by testosterone (growth and reproduction). When the level of testosterone in the body is too low because the cortisol levels are too high, normal growth and reproduction processes are jeopardized.