Health & Medicine - Posted by David Orenstein-Brown on Wednesday, November 14, 2012 11:41 - 0 Comments
Good swimmers? Why sperm length matters
BROWN (US) / U. SHEFFIELD (UK)— Men who have sperm that tend to vary in length—particularly in the tail—often have a lower concentration of sperm that can swim well, a possible sign of fertility trouble.
“Our study reveals that men who produce higher concentrations of competent swimming sperm also demonstrate less variation in the size and shape of those sperm,” says Jim Mossman, a postdoctoral scholar at Brown University and lead author of the paper published in the journal Human Reproduction.
“It suggests that in some cases, testes are working more optimally to produce high numbers of consistently manufactured sperm, and vice versa.”
Researchers apply the segmented line to measure the length of the sperm. (Credit: Jim Mossman/Brown University)
Straight from the Source
At the University of Sheffield, where Mossman did his doctoral studies, he and colleagues measured the heads, midpieces, and flagella of 30 sperm per man, from 103 men randomly selected from a pool of about 500 who were recruited for a larger fertility study.
They also measured other characteristics of each man’s semen, such as sperm concentration and motility, that the World Health Organization recognizes as important markers of fertility.
“The WHO suggests that measurements should be made on multiple components of sperm, but generally it’s only the sperm head that is considered,” Mossman says.
“No one’s ever looked at this before across sperm components. What we show is that measurements on other sperm parts, such as the flagellum that propels the sperm, can provide additional information about the quality and consistency of sperm manufacture.”
The result of the novel analysis yielded two overall findings. One was that men who had higher mean flagellum length, total sperm length, and flagellum-to-head length ratios had higher concentrations of motile sperm. But perhaps the more interesting finding was that the greater the inconsistency of length in the sperm a man manufactures, particularly with regard to the flagellum, the lower his concentration of sperm that could swim well.
“The finding could give clinicians new insight into the diagnosis and treatment of male fertility problems, which accounts for up to 50 percent of the cases where couples struggle to conceive,” Mossman says.
The research suggests that at least in some men, measurable inconsistency in sperm length may be a sign of trouble with his process of making sperm, a process known as spermatogenesis. That trouble, akin to a manufacturing line with poor quality control, could result in a lower concentration of good swimmers.
“This could be an indirect marker of testis function,” Mossman says, acknowledging that there is nothing in the study that suggests what might cause spermatogenesis problems that would result in either inconsistent lengths or low concentrations of motile sperm.
“There are so many factors that govern sperm production, including environmental factors, genetic factors, and their interaction. As an andrologist and evolutionary biologist, I am very interested in what causes this variation and how that affects the phenotype of the sperm and its fertility potential.”
Source: Brown University