Share this article

 Email

 Print

 

Republish this article

The text of this article by Futurity is licensed under a Creative Commons Attribution-No Derivatives License.

More
Health & Medicine

Drug blunts cocaine addiction in mice

Where visual search happens in the brain

Childhood CT scans slightly raise cancer risk

Polio virus engineered to kill brain tumor

Cartilage gets bum rap for osteoarthritis

How to decide if a daily aspirin is harmful

Anxiety drug reduces MS symptoms in mice

‘Vicious cycle’ in brain keeps obesity going

Diabetes rises sharply among UK’s young adults

Researchers and therapists are exploring exercise as part of a drug rehabilitation program in part because the natural high produced by the body during exercise is seen as a potential substitute for the high addicts get from a drug like cocaine.

Researchers at the University of Illinois’ Beckman Institute say those hopes may depend on when exercise takes place relative to drug-taking, based on their findings from a study reported in the European Journal of Neuroscience.

Slides show adult hippocampal neurogenesis in mouse models from (A) four different groups and (B) in runner group. (Credit: Martina Mustroph)

The researchers write that exercise is a “potential intervention for drug addiction because it promotes brain plasticity and may serve as a substitute reward. However, a danger of incorporating exercise into drug rehabilitation programs is that it may strengthen drug learning.”

To test those questions they conducted three studies using mice given exercise and sedentary treatments along with cocaine, and mice given the same treatments and no cocaine. They wanted to determine whether the timing of exercise—either before or after drug exposure—influences the strength of what is called conditioned place preference, which is the place (in this case either grid or hole-textured chambers) the animals prefer after having been conditioned to associate it with cocaine.

Experiments using a running wheel and/or enriched environments to test conditioned place preference (CPP) for cocaine had been done before but not to test for its relation to the timing of drug exposure.

The researchers’ studies showed, in a first-ever finding, opposite effects of wheel running on cocaine CPP that depend critically on the timing of exercise relative to drug conditioning.

The results, they write, suggest that “voluntary exercise strengthens preference for the cocaine-paired texture if exercise is made available prior to drug conditioning” and that, conversely, “exercise appears to weaken preference for the cocaine-paired texture if exercise is made available after conditioning.”

The researchers found that if the animals exercise before the drug conditioning for cocaine, they were better able to learn the association between place and cocaine than sedentary animals. They wrote that just one “drug conditioning session after exercise is sufficient to negate the beneficial effects of an exercise regimen that was completed before drug conditioning. This has important implications for drug relapse.”

“But then it is almost the opposite effect that we found when we had conditioning where we first taught them about the drug-to-context association, and then we let them exercise,” lead author Martina Mustroph of Rhodes’ laboratory says. “That actually seemed to accelerate the extinction of the drug-to-context preference.”

So, exercise can serve to aid associations involving drug-taking, but could also help in extinguishing those associations—if the association is followed by exercise and the drug-taking is totally eliminated.

“Taken together,” the researchers write, “the results suggest that exercise could be a useful intervention to facilitate extinction of conditioned drug associations during abstinence. However, the benefit of exercise could be reversed if a relapse episode occurred after running had primed the brain for plasticity.”

More news from the University of Illinois: http://www.beckman.illinois.edu/news/