Health & Medicine - Posted by Futurity-Jenny Leonard on Thursday, March 5, 2009 11:23 - 3 Comments 
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(No Ratings Yet) Loading ...Drug improves mobility for some MS patients
The drug fampridine slows the progression of Multiple Sclerosis, a disease characterized by the loss of the insulation around nerves.
U. ROCHESTER (US)—A drug that has shown promise treating a debilitating symptom of multiple sclerosis (MS) is one step closer to market. Newly released findings from clinical trials in the United States and Canada show the experimental drug fampridine improves walking ability in some patients.
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Neurologist Andrew Goodman, chief of the Multiple Sclerosis Center at the University of Rochester Medical Center and lead author of the study, says that many MS patients experience a decline in mobility and this disability has a major impact in terms of quality of life.
“As a clinician, I can say that improvement in walking speed could have important psychological value; it may give individuals the potential to regain some of the independence that they may have lost in their daily lives,” says Goodman.
Multiple sclerosis is a disease of the central nervous system and is the most common cause of neurological disability in young adults. Worldwide it is estimated that more than 2.5 million people are affected by MS which is typically characterized by recurrent relapses followed by periods of remission early in its course. The symptoms of the disease vary from person to person, but commonly consist of muscle weakness, gait difficulties, numbness or tingling in arms and legs, difficulty with coordination and balance, blurred vision, and slurred speech. Over time, the effects of the disease tend to become more permanent and debilitating.
While the precise cause is unknown, it is understood that the immune system in individuals with MS attacks myelin, a fatty tissue in the central nervous system that wraps the fibers, or axons, that connect nerve cells. Similar to the insulation on an electrical wire, myelin allows for the efficient conduction of nerve impulses. When myelin is lost or damaged in the disease, signals between nerve cells are delayed, disrupted, or even blocked.
Fampridine appears to improve the transmission of signals in the central nervous system of some MS patients by blocking potassium ion channels. These channels serve as gates on the surface of cells and regulate normal electrical activity. In laboratory experiments involving nerve fibers with myelin that was damaged in a manner that mimics MS, scientists found that blocking these channels results in a recovery of signal conduction.
Goodman says the drug could offer a new way to treat MS and perhaps “become the first drug to improve certain symptoms of the disease.”
While several other drugs have been approved to treat MS, there are no treatments currently available that improve impaired function, such as mobility problems, for people with MS. Acorda Therapeutics has filed a drug application to the U.S. Food and Drug Administration with the goal of bringing the new treatment to market. The FDA review and approval process typically takes about a year to complete.
University of Rochester news: www.rochester.edu/news
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Will yhis drug restore myelin that has been lost due to ms?
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Iam living in Iran and 42 & mining engineer in counsuling eng. company, I expereance Ms diseases , i have problem in Walking (Right Leg) I hope this drug can help me , Please inform me about this drug , Thank you for your Kind,
PS. i used rebif for about 2 years