Health & Medicine - Posted by Jim Erickson-Michigan on Monday, May 10, 2010 16:29 - 10 Comments    
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Can mental trauma alter our biology?

Post-traumatic stress disorder sometimes develops in people who have been exposed to events involving the threat of serious injury or death. New research sheds light on the biological roots of the condition. "Diseases in general, and psychiatric diseases in particular, involve an interplay between social and biological factors," says researcher Monica Uddin. "Traumatic events can get under your skin and literally alter your biology." (Credit: iStockphoto)

U. MICHIGAN (US)—Post-traumatic stress disorder (PTSD) may be caused by actual alterations in the body’s immune system triggered by exposure to a disturbing event.

“We think we have uncovered a key biological step in the process that leads to PTSD,” says Monica Uddin, assistant research scientist in the department of epidemiology at the University of Michigan.

PTSD is a severe anxiety disorder that develops in some people who have been exposed to events involving the threat of serious injury or death.

“Diseases in general, and psychiatric diseases in particular, involve an interplay between social and biological factors.  In the case of PTSD, traumatic events can get under your skin and literally alter your biology, with significant physical and mental consequences,” she says.

The researchers used data from the Detroit Neighborhood Health Study, a five-year project funded by the National Institutes of Health. They examined more than 14,000 genes using DNA from blood samples provided by 100 Detroit residents.

Twenty-three of those individuals suffered from post-traumatic stress disorder. Numerous genes were identified—most of them involved in regulating the immune system—that appeared to be more active in people with PTSD.

Previous studies have posited a link between altered immune function and PTSD. The new findings support that model and go a step further by identifying a specific biochemical reaction that may be involved.

The biochemical reaction is a process called DNA methylation, in which methyl groups (CH3 groups) are added to some of the molecular letters that spell out the genetic code. DNA methylation can alter gene activity, typically reducing it.

For technical reasons, the research team could not directly measure gene activity in the study, so they used methylation patterns as a proxy for gene activity and compared the signatures found in PTSD sufferers to those without the disorder.

Methylation levels of immune-related genes were lower in the PTSD group, suggesting increased activity in those genes. That finding supports a model for PTSD in which exposure to a traumatic event changes gene expression, which in turn alters immune-system activity, leading to the disorder.

“To the best of our knowledge, there have been no studies to date that have documented differences in epigenetic methylation patterns among persons with versus without PTSD,” the authors write.

The findings have potential implications for the treatment. Since DNA methylation states are changeable, it’s conceivable that genes identified in this study could become targets for new drug therapies to treat PTSD, Uddin says.

Researchers from Wayne State University, Harvard University, and the University of Tubingen Medical School in Germany contributed to the research, which received support from the National Institutes of Health, the Robert Wood Johnson Health, Society Scholars Small Grant Program, and from the universities involved.

More University of Michigan news: www.ns.umich.edu/

10 Comments

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Lisabeth Rosenberg
May 11, 2010 13:59

Mind and body are connected. One cannot exist without the other.

Roy Niles
May 11, 2010 14:38

Perceptive experiences alter gene expressions where stress is involved. How much stress is then needed before such experience is seen as a relevant factor in the evolutionary selection process?

Joe Sewell
May 11, 2010 17:03

Adding to Roy’s question: does it take a full-bore traumatic stress event to trigger these changes, or can long-term high-stress levels, such as those found in people with panic/anxiety disorder, also trigger these changes? Is it possible to have PTSD without a singular traumatic event?

Lisabeth Rosenberg
May 13, 2010 14:13

The fact is that stress has an effect, whether long range or short term. Whether the stress toughens the individual or has an destructive effect depends on the resiliency of the individual and the intensity and duration of the trauma. The effect is real and should not be ignored.

Lisabeth Rosenberg
May 13, 2010 14:18

Talking about stress what do you think of this. Good or Bad? Three-year-old girl tightrope walks above tigers http://bit.ly/b9twAJ Maybe it’s all in the conditioning. Lets hope the safety line doesn’t break.

Apparently in China watching this is entertainment.

Marianna Sachse
May 13, 2010 14:46

Adding to Roy and Joe’s comments what about long-term high-stress levels caused by one’s environment? Could that cause a similar biological reaction and, ultimately, PTSD?

alissa
May 14, 2010 3:38

In reference to Roy’s question as to how much stress is needed, one must understand that everyone reacts to stress differently. It may depend on if we are suffering from another psychological disorder, or if we have always been able to handle stress. If I were in a car accident, I may be traumatized by it. However, someone else in the car may not be affected by it. Our brains are all programmed differently. There are studies that have shown via brain scan that we have a biomarker that predicts whether or not we develop PTSD http://bit.ly/a7pN0q

Long term high stress–is that referring to a job or something like that? I believe something that is a long term stress could be repeated abuse, be it psychological or physical.

What many people do not know is that PTSD can also lead to conversion disorder (DSM-IV 300.11) which is also known as non-epilepsy. The symptoms of stress can manifest itself in neuropsychiatric symptoms. http://bit.ly/dAFlYp A person’s reaction to stress can cause non-epileptic seizures (which is diagnosed in a video and eeg) Symptoms are physical i.e. a patient may have muscle weakness and be unable to walk. This is not feigned. It shows as a neurological disorder, as the symptoms are shown this way,but the root of it is psychiatric in nature. Its root is in the amygdala and causes these motor symptoms.

Joe Sewell
May 14, 2010 19:11

Well, the type of long-term stress I was thinking of included stress at home and at work, either as the direct result of what one could call emotional abuse, or through habits and “coping mechanisms” learned through that. For example, if one has a deep-seated notion that he is expected to solve any problem, or cope with any situation, that can cause continued stress when the coping mechanisms fail or when the person dealing with the problems is ill-equipped or ill-trained to deal with a problem or situation.

Peter Barss
May 19, 2010 2:17

Tell it to Palestinian children in occupied Palestine. If over 70% have PTSD, 95% severe anxiety, and 40% moderate or severe depression, is the cause really genetic? Returning their stolen lands and restoring destroyed homes and olive groves should be more effective therapy than targeting genes with drugs.

alissa
May 20, 2010 1:35

Joe: I’m not a therapist or psychiatrist, but it sounds like this is a form of depression. The stress builds up over time due to the abuse. This results in the person developing their own coping mechanism, which may or may not be healthy. Healthy coping is to relieve the stress by expending energy e.g. going to the gym, writing, talking about it. Unhealthy coping mechanism is anger towards inward, i.e. depression. Some ways are by overeating, undereating, cutting. Something could happen that culminates in a “break”, in which the person no longer is able to cope with everything. It takes a lot of energy to survive in circumstances even going thru everyday events. This is more like what I think you were talking about. A person experiences and is dealing with ongoing stresses due to environmental factors (the abuse, work, etc). It becomes no longer tolerable, even if they have used their coping mechanisms. This can result in an event which is when their mind is overloaded and unable to cope any longer.

Peter: The article above refers to post-event and the development of PTSD, which results an altered change in their immune system. This is important to know that it is not organic in nature. Other studies have shown that some people with PTSD do have pre-existing conditions that MAY lead to a person having a higher chance of developing PTSD after a traumatic event. I believe your comment for Israeli occupation leading to PTSD in Palestinian children is more about the occupation than the science behind the mind.

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