"This finding implicates abnormal DNA repair as one of the causes of lupus in people," says Joann Sweasy. "This mouse model of SLE will be useful to study how abnormal DNA repair is linked to lupus and to identify new drugs to treat this disease." (Credit: "lupus" by Sarella via Wikimedia Commons)

Genetic mutation leads to lupus in mice

Researchers have identified a genetic mutation that leads to lupus in mice and say the discovery could open the way for development of therapies that target the mutation in people.

Systemic Lupus Erythematosus (SLE), an autoimmune disease that causes widespread inflammation in internal organs as well as joints and the nervous system. affects five million people around the world. The first sign may be severe joint pain or a butterfly-shaped rash on the face. There is no cure.

For the new study, published in the journal Cell Reports, researchers focused on a gene known as POL B, which functions to repair breaks in DNA. Decreased POL B expression, which results in weakened DNA repair, has been linked to SLE.

To test whether this was true, researchers constructed mouse models with mutated POL B. The mice exhibited decreased expression and much slower DNA synthesis—and subsequently developed disease characteristics that strongly resemble SLE, including dermatitis and renal disease.

“This finding implicates abnormal DNA repair as one of the causes of lupus in people,” says senior author Joann Sweasy, professor of therapeutic radiology and genetics at Yale School of Medicine and a member of Yale Cancer Center.

“This mouse model of SLE will be useful to study how abnormal DNA repair is linked to lupus and to identify new drugs to treat this disease.”

Authors from Janyang University, Seoul, Republic of Korea contributed to the study that was supported by the National Institute of Environmental Health Sciences.

Source: Yale University

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  1. ben kirk

    so am i a mutant!? i have lupus and it is a real downer. it would be a huge benifit to having lupus if i could grow claws out of my hands, or read peoples minds.

  2. Dawn Miller

    so what does this mean exactly i have suffered from lopus many years and have been involved in studies but no help so your saying this lopus disease comes from mice help me better understand what u are saying and what i need to do to better myself ty

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