Drug works better if cancer can’t sleep
U. PITTSBURGH (US) — Keeping cancer cells from entering a state of cellular sleep makes cancer drugs more effective and lowers the chance of cancer recurrence, report researchers.
The findings, which will be published in the August 15 issue of the journal Cancer Research and are available online, are the first to show that it is possible to therapeutically target cancer cells to keep them from entering a cellular state called quiescence, or “cell sleep.”
Quiescence can be a dangerous source of tumor recurrence because cancer drugs don’t typically destroy quiescent cells.
“Successful cancer therapy often is hampered by tumor cell quiescence because these cells remain viable and are a reservoir for tumor progression,” says Anette Duensing, assistant professor of pathology at University of Pittsburgh Cancer Institute (UPCI). “By inhibiting a key regulator of quiescence, we are able to kill a larger fraction of cancer cells.”
Duensing and her colleagues made the discovery while studying gastrointestinal stromal tumors (GISTs), which are uncommon tumors that begin in the walls of the gastrointestinal tract. According to the American Cancer Society, about 5,000 cases of GISTs occur each year in the United States with an estimated five-year survival rate of 45 percent in patients with advanced disease.
GISTs are caused by a single gene mutation, which means they can be successfully treated with the targeted therapy drug imatinib, known by the trade name Gleevec. Unlike traditional chemotherapy, which kills all rapidly dividing cells, targeted therapy stops cancer by interfering with specific molecules needed for tumor growth.
Unfortunately, GISTs rapidly develop resistance to the treatment and complete cancer remission using Gleevec is rare.
A key regulator of the cancer cell sleep process is a protein complex called DREAM, which is named for the multiple proteins involved. Gleevec induces cell sleep using the DREAM complex, which means that the drug intrinsically limits its own effectiveness.
“When we disrupted the DREAM complex in the lab, we significantly increased cancer cell death using Gleevec,” says Duensing. “This underscores the importance of the DREAM complex as a novel drug target worthy of preclinical and clinical investigations.”
The study is a collaboration with the Dana-Farber Cancer Institute in Boston and the Catholic University in Leuven, Belgium.
Researchers from UPCI’s Cancer Virology Program, the Dana-Farber Cancer Institute, the Catholic University of Leuven in Belgium, and the University of Heidelberg School of Medicine in Germany are co-authors of the study.
The American Cancer Society, the GIST Cancer Research Fund, The Life Raft Group, and a number of private donations supported the research.
Source: University of Pittsburgh