"We could use this research to create food products that deliver healthful compounds to the body—potato chips that contain extra vitamins or antioxidants, for example," says Srinivas Janaswamy, who embedded a variety of molecules, including vitamin C, ibuprofen, curcumin, and the flavor compound thymol in raw potato starch granules. (Credit: Tricia G./Flickr)

Could ‘custom’ starch ward off type 2 diabetes?

Inserting “guest” molecules into the natural structure of potato starch could slow down the release of glucose during digestion, new research shows.

Slow, sustained glucose release could help stave off type 2 diabetes and other health problems associated with elevated blood glucose levels.

“Embedding molecules in the water pockets of starch is a simple and practical way of tweaking starch digestion,” says Srinivas Janaswamy, research assistant professor of food science at Purdue University. “Having the ability to slow down the digestion of starch would revolutionize the way we approach a number of health issues.”

Starch is a vital and inexpensive source of energy for humans and is digested at varying speeds, depending on the food product. Rapidly digestible starch is absorbed quickly by the body, leading to a faster accumulation of glucose in the blood, one of the conditions that can cause type 2 diabetes, a chronic ailment that affects the way the body metabolizes glucose.

Cheap prevention?

Janaswamy discovered that embedding “guest” molecules in raw potato starch significantly altered starch digestion rates, in some cases slowing the release of glucose by 22 percent during the initial 120 minutes of in vitro digestion.

“We will now be in a position to tailor treatments to patients by developing starch products with customized glucose release rates,” he says.

Developing food products with controlled starch digestion would be a positive step in preventing type 2 diabetes at minimal cost, he says.

Further, adding beneficial “guest” molecules such as vitamins, drugs, dietary supplements, and flavor compounds to starch could promote health, prevent disease and improve food flavor. In his study, Janaswamy successfully embedded a variety of molecules, including vitamin C, ibuprofen, curcumin, and the flavor compound thymol.

“We could use this research to create food products that deliver healthful compounds to the body—potato chips that contain extra vitamins or antioxidants, for example,” he says.

In the starch lattice

Guest molecules could also provide a means of delivering targeted medicines to the colon, the site of fermentation for certain kinds of starches.

Janaswamy embedded guest molecules in the natural structure of potato starch, which has a lattice-like arrangement of water channels and starch double helices. He dissolved the guest molecules in a solvent and added them to submerged raw potato starch granules. The guest molecules then became entrapped in the water channels of the starch.

“We’re not chemically modifying starch in any way,” he says. “We’re taking advantage of its native structural arrangement at the molecular level to alter digestion rates.”

Because humans cannot digest raw starch, further research is needed to ensure that cooking the starch does not destroy the guest molecules, says Janaswamy.

“I believe that even if the starch is cooked, we will be able to preserve the functionality of the encapsulated molecules,” he says. “This could be a completely new way to add health-promoting compounds to food products.”

The paper appears in Carbohydrate Polymers.

The Whistler Center for Carbohydrate Research provided funding for the research.

Source: Purdue University

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2 Comments

  1. Eric Anderson

    How about not eating the carbohydrate in the first place? Gluconeogenesis provides the small amount of glucose for red blood cells and the liver. Ketogenic diets avoid the spike in blood glucose ad the spiked insulin response. Better Idea? Yes

  2. Fred Brouns

    the text says “Rapidly digestible starch is absorbed quickly by the body, leading to a faster accumulation of glucose in the blood, one of the conditions that can cause type 2 diabetes”.
    indirectly this statement is used to support the development described
    I want to point, however, out that this assumption is not substantiated by any evidence.
    Reducing overall starch consumption and glycemic load, while increasing non starch polysaccharide/fiber consumption seems the more easy way to go for individuals that have overweight and may develop insulin insensitivity and later type 2 diabetes

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