aging

CT scans find clogged arteries in mummies

USC (US) — Ancient people from around the world had plaque buildup in their arteries, even without modern diets or sedentary habits. 

Like nearly 4.6 million Americans, the mummified people also had the clogged arteries that cause blood clots, heart attacks, and strokes, according to new research published in The Lancet.

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The researchers performed CT scans of 137 mummies from across four continents and found artery plaque in every single population studied, from preagricultural hunter-gatherers in the Aleutian Islands to the ancient Puebloans of southwestern United States.

Their findings provide an important twist to one’s understanding of atherosclerotic vascular disease, which is the leading cause of death in the developed world: While modern lifestyles can accelerate the development of plaque on arteries, the prevalence of the disease across human history shows it may have a more basic connection to inflammation and aging.

“This is not a disease only of modern circumstance but a basic feature of human aging in all populations,” says Professor Caleb Finch of University of Southern California (USC), a senior author of the study.

“Turns out even a Bronze Age guy from 5,000 years ago had calcified, carotid arteries,” Finch says, referring to Ötzi the Iceman, a natural mummy who lived around 3200 B.C. and was discovered frozen in a glacier in the Italian Alps in 1991.

With Gregory Thomas of Long Beach Memorial, Finch was part of a team that previously showed Egyptian mummies had calcified patches on their arteries indicative of advanced atherosclerosis (from the Greek “athero,” meaning “gruel,” and “scler,” meaning “hard”).

But ancient Egyptians tended to mummify only royalty or those who had privileged lives. The new study led by Thomas and Randall Thompson of Saint Luke’s Mid America Heart Institute examined mummies from four drastically different climates and diets—and from cultures that mummified regular people, including ancient Peruvians, Ancestral Puebloans, the Unangans of the Aleutian Islands, and ancient Egyptians.

“Our research shows that we are all at risk for atherosclerosis, the disease that causes heart attacks and strokes—all races, diets, and lifestyles,” says Thomas.

“Because of this we all need to be cautious of our diet, weight, and exercise to minimize its impact. The data gathered about individuals from the prehistoric cultures of ancient Peru and the Native Americans living along the Colorado River and the Unangan of the Aleutian Islands is forcing us to think outside the box and look for other factors that may cause heart disease.”

Overall, the researchers found probable or definite atherosclerosis in 34 percent of the mummies studied, with calcification of arteries more pronounced in the mummies that were older at the time of death. Atherosclerosis was equally common in mummies identified as male or female.

“We found that heart disease is a serial killer that has been stalking mankind for thousands of years,” Thompson says. “In the last century, atherosclerotic vascular disease has replaced infectious disease as the leading cause of death across the developed world.

“A common assumption is that the rise in levels of atherosclerosis is predominantly lifestyle-related, and that if modern humans could emulate preindustrial or even preagricultural lifestyles, that atherosclerosis, or at least its clinical manifestations, would be avoided.

“Our findings seem to cast doubt on that assumption, and at the very least, we think they suggest that our understanding of the causes of atherosclerosis is incomplete and that it might be somehow inherent to the process of human aging,” he adds.

The researchers will next seek to biopsy ancient mummies to get a better understanding of the role chronic infection, inflammation, and genetics play in promoting the prevalence of atherosclerosis.

“Atherosclerosis starts very early in life. In the United States, most kids have little bumps on their arteries. Even stillbirths have little tiny nests of inflammatory cells. But environmental factors can accelerate this process,” Finch says, pointing to studies that show larger plaque buildup in children exposed to household tobacco smoking or who are obese.

Source: University of Southern California

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