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Links between brain ‘communities’ affect how we do stuff

The connections within and between regions in our brain may affect our performance of both complex and simple tasks, a new study suggests.

“Think of your brain as you would think of a university… Individuals organize themselves into densely interconnected communities…”

The brain is organized into different subnetworks, or “modules,” that support distinct functions for different tasks, such as speaking, memorizing, and expressing emotion. The researchers examined how high or low brain modularity—the degree to which the modules communicate with one another—impacts performance of simple and complex tasks.

“Think of your brain as you would think of a university,” says Simon Fischer-Baum, an assistant professor of psychology in Rice University’s School of Social Sciences and one of the study’s authors. “Individuals organize themselves into densely interconnected communities, like the dormitories and sports teams, though individuals within these groups also have connections with people outside of those groups.

“Brains are the same way: Brain regions are organized into communities with lots of connections between regions in the community and fewer connections to regions outside of the community. But people’s brains are different. Some people have brains that are better described as having rigid community structure—or higher modularity—while other people have brains without such rigid community structure—or lower modularity,” Fischer-Baum explains.

Throughout the course of the study, modularity was measured on a scale from zero to one. Zero represented low modularity—brains in which every region of the brain is just as likely to communicate with any other region; one represented high modularity—brains that can be divided into communities of brain regions whose members only communicate with each other.

In the study, the researchers had 52 participants (16 men, 36 women) between the ages of 18 and 26 undergo functional magnetic resonance imaging (fMRI), a process that measures brain neural activity by detecting changes associated with blood oxygen levels. The neural activity of each participant was studied by fMRI for 21 minutes while they were at rest.

If neural activity increased and decreased in two areas at the same time over the course of the scan, it was an indicator that the two areas were connected. Using these data to measure which brain areas were connected to each other, the researchers determined the extent to which participants’ brains could be described as having communities of brain regions that communicate only with each other.

The researchers then took the participants through a series of behavioral tasks, including complex tasks that tested their memory while simultaneously doing simple arithmetic and simple tasks such as indicating the direction an arrow was pointing when their attention had been already drawn to the location the arrow would appear.

The researchers found that participants with high-modularity brains were more successful at performing simple tasks than individuals with low-modularity brains. In the experiment measuring reaction time to the arrows, individuals with high modularity performed nearly twice as successfully (a reaction time advantage of 58 milliseconds for knowing where the target would appear) as individuals with low modularity (34 milliseconds advantage).

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However, participants with low-modularity brains had greater success with complex tasks than participants with high-modularity brains. For example, those with low modularity correctly recalled 86 percent of the items in the memory task, while individuals with high modularity correctly recalled only 76 percent.

Fischer-Baum says that this effect can be considered relative to the decline in working memory with age, which is a hallmark of the cognitive effects of aging. Based on previous research, this difference in memory recall between the high- and low-modularity subgroups of highly educated, healthy young adults is roughly equivalent to the difference between memory recall at age 20 and at age 70.

Randi Martin, a professor of psychology in the university’s School of Social Sciences and the lead faculty author on the study, says that one of the major strengths of the study is that the relationship between simple and complex tasks and high and low modularity was predicted by a very general theory of biology proposed by coauthor Michael Deem, a professor of biochemical and genetic engineering and a professor of physics and astronomy at the university.

According to this theory, high-modular systems in general should perform better on simpler tasks that take less time to perform, while low-modular systems in general should perform better on more complex tasks that take more time to perform. This study demonstrates that this general principle of biology applies to cognitive neuroscience.

The authors say the research has important implications for understanding the brain as a network.

“There is an increasing focus in cognitive neuroscience on thinking of cognitive function as emerging from interconnected regions of the brain, rather than existing in a single brain region,” Fischer-Baum says. “While other groups have found correlations between brain network properties and performance on different tasks, our study is the first to show that these relationships can be understood by a more fundamental theory of modularity in biological systems.”

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The researchers will report their work in the journal Cognitive Neuroscience.

The T.L.L. Temple Foundation and the Center for Theoretical Biological Physics under a National Science Foundation grant supported the research.

Source: Rice University

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