The chances that a benign blood disorder will progress into multiple myeloma, a cancer of the blood, are higher for people who carry excess weight.
Multiple myeloma, which develops more often after age 60, is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein. This precancerous condition does not cause symptoms and often goes undiagnosed.
“But our findings show that obesity can now be defined as a risk factor for developing multiple myeloma through this condition,” says Su-Hsin Chang, assistant professor of surgery in the Division of Public Health Sciences at Washington University in St. Louis.
“For patients diagnosed with MGUS, maintaining a healthy weight may be a way to prevent the progression to multiple myeloma, if further confirmed by clinical trials.”
For the study, published in the Journal of the National Cancer Institute, researchers analyzed data from a US Department of Veterans Affairs database, identifying 7,878 patients, predominately men, diagnosed with MGUS from October 1999 through December 2009.
Among these patients, 39.8 percent were overweight and 33.8 percent were obese. Researchers then tracked whether the patients developed multiple myeloma. They found that 4.6 percent of overweight patients (followed for a median of 5.75 years) and 4.3 percent of obese patients (followed for a median of 5.9 years) developed multiple myeloma, compared with 3.5 percent of people at normal weight (followed for a median of 5.2 years)—a difference that is statistically significant.
Overweight and obese MGUS patients had a 55 percent and 98 percent higher risk of progression to multiple myeloma, respectively, than normal-weight MGUS patients.
African-American men also were more likely than their Caucasian counterparts to experience a progression from MGUS to multiple myeloma.
MGUS is caused by elevated levels of an antibody protein, known as M protein, found in 3 percent of people over age 50. By itself, MGUS is difficult to diagnose and often does not warrant treatment.
“The diagnosis is usually by accident, often driven by tests performed for the diagnosis or management of other conditions,” Chang says. “Although our study does not directly suggest screening for MGUS, regular check-ups can help physicians monitor whether MGUS is progressing to other disorders, including multiple myeloma.”
“Based on our finding that being overweight or obese is a risk factor for multiple myeloma in MGUS patients, and since extra weight is a modifiable risk factor, we hope that our results will encourage intervention strategies to prevent the progression of this condition to multiple myeloma as soon as MGUS is diagnosed. Also, for black people diagnosed with MGUS, close monitoring of the disease progression, in addition to maintaining a healthy weight, should be prioritized,” Chang says.
“In the future, we will look at whether healthy weight loss is inversely associated with the progression of multiple myeloma in MGUS patients or how weight change plays a role in the progression of MGUS to multiple myeloma.”
The Foundation for Barnes-Jewish Hospital; Siteman Cancer Center, the National Institutes of Health, the Agency for Healthcare Research and Quality, and the American Cancer Society funded the work.