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ADHD kids have different DNA

CARDIFF U. (UK) — Children with attention deficit hyperactivity disorder are more likely to have small segments of their DNA duplicated or missing than other children.

The first study to find a genetic link to ADHD also finds significant overlap between these segments, known as copy number variants (CNVs), and genetic variants implicated in autism and schizophrenia.

Researchers say the findings prove strong evidence that ADHD is a neurodevelopmental disorder—in other words, that the brains of children with the disorder differ from those of other children.

Details are published in The Lancet.

“We hope that these findings will help overcome the stigma associated with ADHD,” says Anita Thapar, professor of child and adolescent psychiatry at Cardiff University.

“Too often, people dismiss ADHD as being down to bad parenting or poor diet. As a clinician, it was clear to me that this was unlikely to be the case.

“Now we can say with confidence that ADHD is a genetic disease and that the brains of children with this condition develop differently to those of other children,” she says.

ADHD is one of the most common mental health disorders in childhood, affecting around one in 50 children in the UK. Children with ADHD are excessively restless, impulsive and distractible, and experience difficulties at home and in school.

Although no cure exists for the condition, symptoms can be reduced by a combination of medication and behavioral therapy.

The condition is highly heritable–children with ADHD are statistically more likely to also have a parent with the condition and a child with an identical twin with ADHD has a three in four chance of also having the condition.

Until now there has been no direct evidence that the condition is genetic and there has been much controversy surrounding its causes, which some people have put down to poor parenting skills or a sugar-rich diet.

Genomes of 366 children, all of whom had been given a clinical diagnosis of ADHD, were analyzed against more than 1,000 control samples in search of variations in their genetic make-up that were more common in children with the condition.

“Children with ADHD have a significantly higher rate of missing or duplicated DNA segments compared to other children and we have seen a clear genetic link between these segments and other brain disorders,” explains Nigel Williams, senior lecturer in the department of psychological medicine who took part in the study.

“These findings give us tantalizing clues to the changes that can lead to ADHD,” he adds

The researchers found that rare CNVs were almost twice as common in children with ADHD compared to the control sample—and even higher for children with learning difficulties. CNVs are particularly common in disorders of the brain.

There was also significant overlap between CNVs identified in children with ADHD and regions of the genome which are known to influence susceptibility to autism and schizophrenia.

While these disorders are currently thought to be entirely separate, there is some overlap between ADHD and autism in terms of symptoms and learning difficulties. The new research suggests there may be a shared biological basis to the two conditions.

The most significant overlap was found at a particular region on chromosome 16 which has been previously implicated in schizophrenia and other major psychiatric disorders and spans a number of genes including one known to play a role in the development of the brain.

“ADHD is not caused by a single genetic change, but is likely caused by a number of genetic changes, including CNVs, interacting with a child’s environment,” explains Kate Langley from Cardiff’s School of Medicine.

The research was funded by the Wellcome Trust, with additional support from Action Medical Research, the Medical Research Council and the European Union.

More news from Cardiff University: www.cardiff.ac.uk/news/

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